N-of-1 trials to improve sleep 2023

Traditionally, treatment guidelines and health intervention recommendations are developed based on results of large cohort studies or randomized controlled trials (RCTs). However, the analysis of such studies only yields estimates of average effects. Hence, these results do not allow meaningful predictions whether an intervention will help a given single individual. In the advent of digital solutions, personalized approaches have been on the rise. N-of-1 trials and other modern study designs allow to derive individual treatment effects, but also to use the data to obtain and improve the precision of population-level effect estimates of health interventions.From week 2-4, every student will plan and then later perform an N-of-1 trial and investigate the impact of self-determined interventions on sleep quality. The trial will be designed, implemented, and then run using the StudyU platform (studyu.health). This data will be anonymized, used throughout the course to illustrate the statistical methods, and potentially used in a joint publication afterwards.Feasibility of N-of-1 trials to improve sleep using the StudyU application (https://studyu.health). This study was conducted during the course "Digital N-of-1 trials and their application" at Hasso Plattner Institute inthe summer term 2023.